Ryanair is selling cheap flights from Madrid, Spain to Prague, Czech Republic for as low as €45 return! That works out to a cost of just 2.1 (Euro) Cents Per Mile for this 2200 mile journey.

The fare only includes a small carry-on bag placed under the seat, and you need to pay extra if you want to use the overhead storage or to check bags.

Our data shows the lowest prices are available in September 2021. See the link(s) below for dates and prices.

Sample date(s) with Kiwi.com booking link

Aug 12 – Aug 26 (€52)

Aug 17 – Aug 26 (€64)

Aug 19 – Aug 26 (€48)

Aug 21 – Aug 26 (€64)

Sep 4 – Sep 21 (€59)

Sep 11 – Sep 21 (€49)

Sep 11 – Sep 28 (€49)

Sep 14 – Sep 21 (€50)

Sep 14 – Sep 28 (€50)

Sep 25 – Sep 28 (€45)

Are you looking for an apartment to rent for your stay in Prague, Czech Republic? Check out what Vrbo.com has to offer!

We post many cheap flights like this one from Madrid, Spain to Prague, Czech Republic every single day, so have a look at our Travel Deals page, or check out the related posts below!

Note: Prices are valid at the time of publishing this post, but may change in the future.

COVID-19 Note: During these uncertain times, please make sure to check the relevant Coronavirus restrictions for your destination before you book and before you fly. We recommend also checking the refund policy of the airline, as well as purchasing travel insurance for your trip.