KLM is selling cheap flights from Madrid, Spain to San Francisco, United States for as low as €225 return! That works out to a cost of just 2.2 (Euro) Cents Per Mile for this 10100 mile journey.

The fare only includes carry-on luggage, so you need to pay extra if you want to check bags.

Our data shows the lowest prices are available in January 2022. See the link(s) below for dates and prices.

Sample date(s) with Kiwi.com booking link

Oct 1 – Oct 10 (€281)


Oct 1 – Oct 12 (€256)


Oct 6 – Oct 14 (€233)


Oct 6 – Oct 20 (€240)


Oct 11 – Oct 19 (€249)


Nov 8 – Nov 15 (€240)


Nov 11 – Nov 15 (€249)


Jan 10 – Jan 20 (€225)


Feb 3 – Feb 14 (€225)


Jun 1 – Jun 12 (€276)

Are you looking for an apartment to rent for your stay in San Francisco, United States? Check out what Vrbo.com has to offer!

We post many cheap flights like this one from Madrid, Spain to San Francisco, United States every single day, so have a look at our Travel Deals page, or check out the related posts below!

Note: Prices are valid at the time of publishing this post, but may change in the future.

COVID-19 Note: During these uncertain times, please make sure to check the relevant Coronavirus restrictions for your destination before you book and before you fly. We recommend also checking the refund policy of the airline, as well as purchasing travel insurance for your trip.